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Wiki for the proton CT project

Documentation

Documentation on how to install and use the involved software packages, the development workflow, etc.

Publications

List of interesting publications for the project.

From WP1:

Review articles on proton CT

  • G. Poludniowski, N.M. Allinson, P.M. Evans, Proton radiography and tomography with application to proton therapy, The British Journal of Radiology. 88 (2015) 20150134. doi:10.1259/bjr.20150134.
  • C. Civinini, Tracking for pCT - global status update, (2013).

From PRaVDA

  • M. Esposito, T. Anaxagoras, P.M. Evans, S. Green, S. Manolopoulos, J. Nieto-Camero, D.J. Parker, G. Poludniowski, T. Price, C. Waltham, N.M. Allinson, CMOS Active Pixel Sensors as energy-range detectors for proton Computed Tomography, Journal of Instrumentation. 10 (2015) C06001–C06001. doi:10.1088/1748-0221/10/06/C06001.
  • M. Esposito, T. Anaxagoras, A. Fant, K. Wells, A. Konstantinidis, J.P.F. Osmond, P.M. Evans, R.D. Speller, N.M. Allinson, DynAMITe: a wafer scale sensor for biomedical applications, Journal of Instrumentation. 6 (2011) C12064–C12064. doi:10.1088/1748-0221/6/12/C12064.
  • T. Price, M. Esposito, G. Poludniowski, J. Taylor, C. Waltham, D.J. Parker, S. Green, S. Manolopoulos, N.M. Allinson, T. Anaxagoras, P. Evans, J. Nieto-Camero, Expected proton signal sizes in the PRaVDA Range Telescope for proton Computed Tomography, Journal of Instrumentation. 10 (2015) P05013–P05013. doi:10.1088/1748-0221/10/05/P05013.
  • G. Poludniowski, N.M. Allinson, P.M. Evans, Proton computed tomography reconstruction using a backprojection-then-filtering approach, Physics in Medicine and Biology. 59 (2014) 7905–7918. doi:10.1088/0031-9155/59/24/7905.
  • G. Poludniowski, N.M. Allinson, T. Anaxagoras, M. Esposito, S. Green, S. Manolopoulos, J. Nieto-Camero, D.J. Parker, T. Price, P.M. Evans, Proton-counting radiography for proton therapy: a proof of principle using CMOS APS technology, Physics in Medicine and Biology. 59 (2014) 2569–2581. doi:10.1088/0031-9155/59/11/2569.

From Lomda Linda

  • T. Plautz, V. Bashkirov, V. Feng, F. Hurley, R.P. Johnson, C. Leary, S. Macafee, A. Plumb, V. Rykalin, H.F.-W. Sadrozinski, K. Schubert, R. Schulte, B. Schultze, D. Steinberg, M. Witt, A. Zatserklyaniy, 200 MeV Proton Radiography Studies With a Hand Phantom Using a Prototype Proton CT Scanner, IEEE Transactions on Medical Imaging. 33 (2014) 875–881. doi:10.1109/TMI.2013.2297278.
  • R. P. Johnson, V. Bashkirov, L. DeWitt, V. Giacometti, R. F. Hurley, P. Piersimoni, T. E. Plautz, H. F. W. Sadrozinski, K. Schubert, R. Schulte, B. Schultze, A. Zatserklyaniy, A Fast Experimental Scanner for Proton CT: Technical Performance and First Experience With Phantom Scans, IEEE Transactions on Nuclear Science. 63 (2016) 52–60. doi:10.1109/TNS.2015.2491918.
  • R. Schulte, V. Bashkirov, T. Li, Z. Liang, K. Mueller, J. Heimann, L.R. Johnson, B. Keeney, H.-W. Sadrozinski, A. Seiden, others, Conceptual design of a proton computed tomography system for applications in proton radiation therapy, Nuclear Science, IEEE Transactions on. 51 (2004) 866–872.
  • H.-W. Sadrozinski, R.P. Johnson, S. Macafee, A. Plumb, D. Steinberg, A. Zatserklyaniy, V.A. Bashkirov, R.F. Hurley, R.W. Schulte, Development of a head scanner for proton CT, Nuclear Instruments and Methods in Physics Research Section A: Accelerators, Spectrometers, Detectors and Associated Equipment. 699 (2013) 205–210.
  • H.-W. Sadrozinski, V. Bashkirov, M. Bruzzi, L.R. Johnson, B. Keeney, G. Ross, R.W. Schulte, A. Seiden, K. Shahnazi, D.C. Williams, others, Issues in proton computed tomography, Nuclear Instruments and Methods in Physics Research Section A: Accelerators, Spectrometers, Detectors and Associated Equipment. 511 (2003) 275–281.
  • R.W. Schulte, A.J. Wroe, New developments in treatment planning and verification of particle beam therapy, Translational Cancer Research. 1 (2012) 184–195.
  • V.A. Bashkirov, R.W. Schulte, R.F. Hurley, R.P. Johnson, H.F.-W. Sadrozinski, A. Zatserklyaniy, T. Plautz, V. Giacometti, Novel scintillation detector design and performance for proton radiography and computed tomography, Medical Physics. 43 (2016) 664–674. doi:10.1118/1.4939255.
  • R.W. Schulte, V. Bashkirov, R. Johnson, H.-W. Sadrozinski, K.E. Schubert, Overview of the LLUMC/UCSC/CSUSB Phase 2 Proton CT Project, Transactions of the American Nuclear Society. 106 (2012) 59.
  • R. Johnson, V.A. Bashkirov, V. Giacometti, R.F. Hurley, P. Piersimoni, T. Plautz, Results from a pre-clinical head scanner for proton CT, (2014).
  • R.F. Hurley, R.W. Schulte, V.A. Bashkirov, G. Coutrakon, H.-W. Sadrozinski, B. Patyal, The Phase I Proton CT Scanner and Test Beam Results at LLUMC, invited, Transactions of the American Nuclear Society. 106 (2012) 63.
  • R.P. Johnson, J. DeWitt, C. Holcomb, S. Macafee, H.F.-W. Sadrozinski, D. Steinberg, Tracker Readout ASIC for Proton Computed Tomography Data Acquisition, IEEE Transactions on Nuclear Science. 60 (2013) 3262–3269. doi:10.1109/TNS.2013.2274663.
  • R.F. Hurley, R.W. Schulte, V.A. Bashkirov, A.J. Wroe, A. Ghebremedhin, H.F.-W. Sadrozinski, V. Rykalin, G. Coutrakon, P. Koss, B. Patyal, Water-equivalent path length calibration of a prototype proton CT scanner, Medical Physics. 39 (2012) 2438. doi:10.1118/1.3700173.

From the PRIMA project at INFN

  • M. Scaringella, M. Bruzzi, M. Bucciolini, M. Carpinelli, G.A.P. Cirrone, C. Civinini, G. Cuttone, D.L. Presti, S. Pallotta, C. Pugliatti, N. Randazzo, F. Romano, V. Sipala, C. Stancampiano, C. Talamonti, E. Vanzi, M. Zani, A proton Computed Tomography based medical imaging system, Journal of Instrumentation. 9 (2014) C12009–C12009. doi:10.1088/1748-0221/9/12/C12009.
  • C. Civinini, M. Bruzzi, M. Bucciolini, M. Carpinelli, G.A.P. Cirrone, G. Cuttone, D. Lo Presti, S. Pallotta, C. Pugliatti, N. Randazzo, others, Recent results on the development of a proton computed tomography system, Nuclear Instruments and Methods in Physics Research Section A: Accelerators, Spectrometers, Detectors and Associated Equipment. 732 (2013) 573–576.
  • E. Vanzi, M. Bruzzi, M. Bucciolini, G.A.P. Cirrone, C. Civinini, G. Cuttone, D. Lo Presti, S. Pallotta, C. Pugliatti, N. Randazzo, F. Romano, M. Scaringella, V. Sipala, C. Stancampiano, C. Talamonti, M. Zani, The PRIMA collaboration: Preliminary results in FBP reconstruction of pCT data, Nuclear Instruments and Methods in Physics Research Section A: Accelerators, Spectrometers, Detectors and Associated Equipment. 730 (2013) 184–190. doi:10.1016/j.nima.2013.05.193.
  • M. Scaringella, M. Brianzi, M. Bruzzi, M. Bucciolini, M. Carpinelli, G.A.P. Cirrone, C. Civinini, G. Cuttone, D. Lo Presti, S. Pallotta, others, The PRIMA (Proton Imaging) collaboration: development of a proton Computed Tomography apparatus, Nuclear Instruments and Methods in Physics Research Section A: Accelerators, Spectrometers, Detectors and Associated Equipment. 730 (2013) 178–183.
  • V. Sipala, N. Randazzo, D.L. Presti, C. Stancampiano, M. Bruzzi, M. Bucciolini, S. Pallotta, M. Scaringella, C. Talamonti, M. Tesi, others, Upgrade of the proton Computed Tomography system of the PRIMA project, PoS (RD11). 13 (2011). http://www.researchgate.net/publication/230709286_Upgrade_of_the_proton_Computed_Tomography_system_of_the_PRIMA_project_Speaker/file/9fcfd5034f8b703175.pdf (accessed January 15, 2015).

Historical

  • K.M. Hanson, C.A. Taylor, M.A. Paciotti, R.J. Macek, D.B. Laubacher, R.L. Hutson, T.M. Cannon, J.N. Bradbury, Computed tomography using proton energy loss, Physics in Medicine and Biology. 26 (1981) 965.
  • M. Urie, M. Goitein, W.R. Holley, G.T. Chen, Degradation of the Bragg peak due to inhomogeneities, Physics in Medicine and Biology. 31 (1986) 1.
  • K.M. Hanson, J.N. Bradbury, R.A. Koeppe, R.J. Macek, D.R. Machen, R. Morgado, M.A. Paciotti, S.A. Sandford, V.W. Steward, Proton computed tomography of human specimens, Physics in Medicine and Biology. 27 (1982) 25.
  • A.M. Koehler, Proton Radiography, Science. 160 (1968) 303–304.
  • M. Gotein, The measurement of tissue heterodensity to guide charged particle radiotherapy, International Journal of Radiation Oncology Biological Physics. 3 (1977) 27–33.
  • B. Schaffner, E. Pedroni, The precision of proton range calculations in proton radiotherapy treatment planning: experimental verification of the relation between CT-HU and proton stopping power, Physics in Medicine and Biology. 43 (1998) 1579.
  • H.F.-W. Sadrozinski, V. Bashkirov, B. Keeney, L.R. Johnson, S.G. Peggs, G. Ross, T. Satogata, R.W.M. Schulte, A. Seiden, K. Shanazi, D.C. Williams, Toward Proton Computed Tomography, IEEE Transactions on Nuclear Science. 51 (2004) 3–9. doi:10.1109/TNS.2003.823044.

On proton CT reconstruction with some novel approaches

  • R. Rescigno, C. Bopp, M. Rousseau, D. Brasse, A pencil beam approach to proton computed tomography, Medical Physics. 42 (2015) 6610–6624. doi:10.1118/1.4933422.
  • C.T. Quiñones, J.M. Létang, S. Rit, Filtered back-projection reconstruction for attenuation proton CT along most likely paths, Physics in Medicine and Biology. 61 (2016) 3258–3278. doi:10.1088/0031-9155/61/9/3258.
  • C. Bopp, J. Colin, D. Cussol, C. Finck, M. Labalme, M. Rousseau, D. Brasse, Proton computed tomography from multiple physics processes, Physics in Medicine and Biology. 58 (2013) 7261–7276. doi:10.1088/0031-9155/58/20/7261.
  • M. Bruzzi, N. Blumenkrantz, J. Feldt, J. Heimann, H.F.-W. Sadrozinski, A. Seiden, D.C. Williams, V. Bashkirov, R. Schulte, D. Menichelli, M. Scaringella, G.A.P. Cirrone, G. Cuttone, N. Randazzo, V. Sipala, D. Lo Presti, Prototype Tracking Studies for Proton CT, IEEE Transactions on Nuclear Science. 54 (2007) 140–145. doi:10.1109/TNS.2006.889642.
  • C. Bopp, R. Rescigno, M. Rousseau, D. Brasse, Quantitative proton imaging from multiple physics processes: a proof of concept, Physics in Medicine and Biology. 60 (2015) 5325–5341. doi:10.1088/0031-9155/60/13/5325.
  • C. Bopp, R. Rescigno, M. Rousseau, D. Brasse, The impact of tracking system properties on the most likely path estimation in proton CT, Physics in Medicine and Biology. 59 (2014) N197–N210. doi:10.1088/0031-9155/59/23/N197.

Meetings

Notes and slides from the project meetings

Workshops

Slides from the project workshops

Workpackages

Sections for the different work packages

People

Contact info of involved people

Links

Link collection of topics regarding the project

Getting started

  • Note: ASK is a placeholder that marks questions
  • Note: Search function is not ideal. It doesn't find all occurences of the search term, e.g. aries finds libraries but not aries.bccs